Are GMOs safe?
At a Glance
In the three decades since the introduction of GMO crops, there have been more than 2,000 studies evaluating health and environmental aspects of genetically engineered products. The vast majority of studies has found nothing to indicate that GM foods represent a health threat. The consensus among scientists is that gene altered crops offer no more risk than those developed through conventional breeding techniques.
More than 275 independent science organizations from around the world have concluded that foods grown from genetically engineered seeds pose no unique health concerns. More 110 Nobel laureates issued a joint communique in June 2012, stating: “Scientific and regulatory agencies around the world have repeatedly and consistently found crops and foods improved through biotechnology to be as safe as, if not safer than those derived from any other method of production.” After a two-year evaluation, in the most comprehensive evaluation of GM crops ever undertaken, the US National Academy of Sciences concluded that genetically engineered crops have not caused increases in cancer, obesity, gastrointestinal illnesses, kidney disease, autism or allergies: there are “no differences that would implicate a higher risk to human health from eating GE foods than from eating their non-GE counterparts.” The Union of German Academies of Science and Humanities, echoing dozens of other global science groups, has written, “in some cases food from GM plants appears to be superior in respect to health.”
Not one mainstream independent science or health organization has expressed unique concerns with GM foods. A small number of scientists and many anti-GMO activists dispute the notion of a scientific consensus, arguing that many safety studies were conducted by industry scientists, some studies point to potential health or safety problems and future risks remain unknown.
Science and Politics
…the scarcity and contradictory nature of the scientific evidence published to date prevents conclusive claims of safety, or of lack of safety, of GMOs. Claims of consensus on the safety of GMOs are not supported by an objective analysis of the refereed literature.
It’s a position often repeated by some advocacy groups and journalists.
“The science just hasn’t been done.”
– Charles Benbrook, Organic Trade Association
“There is no credible evidence that GMO foods are safe to eat.”
– David Schubert, Salk Institute of Biological Studies
“[The] research [on GMOs] is scant…. Whether they’re killing us slowly—contributing to long-term, chronic maladies—remains anyone’s guess.”
– Tom Philpott, Mother Jones
“Genetically modified (GM) foods should be a concern for those who suffer from food allergies because they are not tested….”
These statements and similar claims by a small group of scientists have left open in some people’s minds the possibility that GMOs present threats to human health by creating new allergens or from unintended consequences of gene changes. This position is unsupported by the volumes of studies conducted on GMO crops, one of the most regulated areas of agriculture. There is no plausible biological mechanism for GMO modifications as a general breeding process to cause harm, they conclude. Almost half of the living Nobel laureates issued a joint statement in June 2016 endorsing the global consensus on the safety of GM crops and foods:
Scientific and regulatory agencies around the world have repeatedly and consistently found crops and foods improved through biotechnology to be as safe as, if not safer than those derived from any other method of production. There has never been a single confirmed case of a negative health outcome for humans or animals from their consumption. Their environmental impacts have been shown repeatedly to be less damaging to the environment, and a boon to global biodiversity.
The US National Academy of Sciences confirmed the consensus in May 2016, concluding its review of more than 1000 studies, writing: “The committee could not find persuasive evidence of adverse health effects directly attributable to consumption of GE foods.”
It further concluded there were some safe and health benefits to GMOs: “There is some some evidence that GE insect-resistant crops have had benefits to human health by reducing insecticide poisonings and decreasing exposure to fumonisins.” The panel found “no justification for the labeling of GM foods for safety reasons, as we found no identifiable concerns.”
The National Academies evaluation echoed the conclusions of the European Commission, which has overseen independent research on crop biotechnology since 1986 at a cost of more than $350 million. It’s most recent publication covering 2001-2010, “A decade of EU-funded research”:
The main conclusion to be drawn from the efforts of more than 130 research projects, covering a period of more than 25 years of research, and involving more than 500 independent research groups, is that biotechnology, and in particular GMOs, are no more risky than conventional plant breeding technologies.
In 2013, Italian scientists with no connection to the biotechnology industry published an analysis of ten years of studies, 1,783 in total, into GMO crops:
We have reviewed the scientific literature on GE crop safety for the last 10 years that catches the scientific consensus matured since GE plants became widely cultivated worldwide, and we can conclude that the scientific research conducted so far has not detected any significant hazard directly connected with the use of GM crops.
Humans are only part of the safety equation, however, when evaluating the safety of agricultural products. A sizable percentage of GM crops are used in animal feed. Europe, which tightly restricts GMO cultivation, is the world’s largest regional importer of GM grain. A November 2014 study by University of California-Davis animal geneticist Alison Van Eenennaam and assistant Amy Young examined 29 years of livestock productivity and health data. The period covered animals before and after the introduction of GMO animal feed in 1996. Today, these animals consume 70-90% of the world’s genetically engineered crops. In the US alone, animal agriculture produces over 9 billion food-producing animals annually, and more than 95% of these animals consume feed containing GE ingredients. The researchers found no evidence that GMO animal feed has had a negative impact on livestock.
An extensive search of peer-reviewed literature and field observations of animals fed diets containing GE crop products have revealed no unexpected perturbations or disturbing trends in animal performance or health indicators. Likewise, it is not possible to distinguish any differences in the nutritional profile of animal products following consumption of GE feed.
It’s estimated that many trillions of animals have consumed GM feed since their introduction. If GE feed is causing unusual problems, dead and sick animals would litter farms around the world. Yet there are no anecdotal reports of mass or even isolated health animal problems. No human health problem of any kind has yet been linked to the consumption of GM foods.
A 2015 PEW survey of the world’s largest independent scientist group, the American Association for the Advancement of Science, found 88% view GM foods as safe—a stronger consensus than believe humans are a driving factor in global warming.
Many of the same groups have issued consensus statements on both climate change and GMO safety.
Still, the public remains skeptical, with 37% telling PEW in January 2015 that GM foods are “generally unsafe.” That view is supported by a small minority of scientists, most of whom have formed an anti-GMO advocacy organization known as ENSSER—European Network of Scientists for Social and Environmental Responsibility. Key ENSEER members were behind a 2013 Environmental Sciences Europe ‘no consensus’ declaration:
Whether to continue and expand the introduction of GM crops and foods into the human food and animal feed supply, and whether the identified risks are acceptable or not, are decisions that involve socioeconomic considerations beyond the scope of a narrow scientific debate and the currently unresolved biosafety research agendas. These decisions must therefore involve the broader society.
There have been some studies, widely reviewed and rejected by international regulatory and science organizations, suggesting that GMOs are responsible for, or could lead to, a variety of illnesses. The most oft cited is the 2012 study published in Food and Chemical Toxicology by French biologist Gilles-Éric Séralini, who claimed that rats fed genetically engineered corn and/or the herbicide glyphosate, which is often paired with the GMO crop, developed grotesque cancerous tumors.
The work was retracted after criticism from scientists and oversight bodies that the study used cancer-prone rats, controls were shoddy and data cherry-picked (e.g. data showed some rats fed glyphosate actually had few tumors, which the authors did not acknowledge in their commentary). Séralini and anti-GMO groups claimed the retracing journal bowed to industry pressure. The study was republished, without peer review, in Environmental Sciences Europe, a low impact journal (bottom ten percent of all environmental sciences journals), to much criticism.
GMO critics cite other studies—almost all in low impact or what are known as predatory, pay-for-play journals—many of which are prominently displayed on anti-biotechnology websites, such as Collective Evolution—10 Scientific Studies Proving GMOs Can Be Harmful. Mainstream scientists have responded (see fore example 10 studies proving GMOs are harmful? Not if science matters by molecular geneticist Layla Katiraee). There are also claims, often accompanied by correlation charts, that GMOs have caused an increase in allergies or cancers, issues evaluated in detail by the National Academies report. It concluded that there is no evidence that GMOs have caused increases in cancer, obesity, gastrointestinal illnesses, kidney disease, autism or allergies.
Skeptics of GMO foods, such as the Union of Concerned Scientists (UCS), base their criticisms in part on the precautionary principle —“not enough is known” about the long term effects, they say. Many activists claim there have been no long-term studies other than the Séralini study, but that is not accurate. There have been dozens of multigenerational and long-term GMO studies on animals. Other critics suggest GMOs should not be banned until human studies have been conducted–which scientists say could not be done and would be unethical.
Critics, like UCS, also say GMO research has been “tightly controlled by the industry”— a concern echoed in a 2009 Scientific American blog still widely circulated among activists. Scientists say GMO companies did restrict seed availability for studies years ago, but that problem no longer exists—as evidenced in part by the accessibility and use of patented seeds in studies by GMO-critical scientists. Many studies are industry funded by design—companies submit safety data as part of the regulatory process. But there are also studies, including hundreds funded by the European Commission, with no industry links. The independent website Biology Fortified lists more than 1000 studies in its database–more than one-third of which were independently funded.
There also have been questions about whether GMOs represent a threat to people with allergies. It’s a relevant question when you consider that much of GMO technology to date has involved the mixing of genetic material from unrelated organisms, creating the potential for a new food item to produce allergens. Every unique GMO food is tested at the the Allergen Online database at the University of Nebraska, Lincoln, which is used by GM developers, the food industry and regulatory agencies for evaluating the potential allergenicity of novel proteins and GMOs. The database is independently managed by internationally recognized allergy experts who review and vote on allergen inclusion in a yearly process.
Such testing proved essential in the mid 1990s when a soybean that contained genetic material from the Brazil nut was developed. The transgenic soybean produced proteins that could be dangerous to people with sensitivity to Brazil nuts. Pioneer Hi-Bred International had planned to market the soybeans as animal feed, but terminated the project over concerns that those soybeans might accidentally find their way into the human food supply. Critics cite this as a warning flag; GMO supporters cite it as support for its belief that the ‘system works’.
Despite extensive testing, critics complain there’s still a chance that unknown allergens could be produced during the genetic engineering process. It’s true. But experts say the risk is low—significantly lower than the risk accompanying the introduction of a new conventional food from one country to another. Context is important: the allergic threat posed by Pioneer’s Brazil nuts was far less than the known allergic problems linked to many conventional foods, such as peanuts and kiwi fruit, said professor Richard Goodman, who runs the Nebraska database:
“[I]n principle, you might find a heretofore unknown reaction in some individuals to a protein not yet listed in the database. Certainly not every protein of the millions of proteins from every food or inhalation source of allergy has been tested for allergies. But those proteins occur in non-GMO sources” as well. When a new genetically modified crop is created, “only one or a few new proteins are made,” he added, “and those are evaluated specifically for potential risks of allergy.”
THIS is why scientists stress the number of studies that have examined genetically engineered crops. THIS is why scientists stress the statements made by reputable scientific institutions about GMOs.
Related GMO FAQs
- Are GMOs to blame for the mass suicides of Indian farmers?
- Why are there no long-term GMO safety studies or studies on humans?
- 11 GMO Myths, Part II: Do GMOs pose health and ecological dangers? Michael Hess and Peter Hess, March 10, 2016
- Why There are no long term GMO studies on humans, Layla Katiraee, January 13, 2016
- The story behind Séralini’s disappearing GMOs-are-toxic study, and the journal that published it, Nicholas Staropoli, January 28, 2016
- Autism increase mystery solved: No, it’s not vaccines, GMOs glyphosate–or organic foods, Arvind Suresh, October 13, 2015
- With 2000+ global studies affirming safety, GM foods among most analyzed subjects in science, JoAnna Wendel and Jon Entine, October 8, 2013
- Nothing to Sneeze at: the Allergenicity of GMOs, Charles Xu, PhD candidate in the Biological and Biomedical Sciences program, Harvard University, 2015
- Unhealthy Fixation, William Saletan, Slate, July 15, 2015
- Why no one will ever “prove that GMOs are safe, Layla Katiraee, Biology Fortified, May 20, 2015
- Why Jon Entine’s “trillion meal study” won’t save us from GMO dangers, Claire Robinson, GMWatch, September 29, 2014
- Will the National Academy of Sciences Fumble Assessment of GMOs? Jon Entine, Forbes, September 23, 2014
- An overview of the last 10 years of genetically engineered crop safety research, Alessandro Nicolia, Alberto Manzo, Fabio Veronesia & Daniele Rossellini, Critical Reviews in Biology, September 13, 2013
- Genetically engineered food: Allergic to regulations? Nathanael Johnson, Grist, July 30, 2013